L. Murphy

Diminished Immune Cell Adhesion in Hypoimmune ICAM-1 Knockout Pluripotent Stem Cells

This paper identifies ICAM-1 as a novel hypoimmune target in human pluripotent stem cells, showing that its knock-out reduces immune cell adhesion and enhances graft survival.

Birds affected by a 2021 avian mortality event are strongly associated with supplemental feeding and ground foraging behaviors

The paper investigates factors associated with a 2021 avian mortality event, finding that birds consuming supplemental feed and ground foragers were significantly represented in affected samples.

Mating-compatibility genes employed as diagnostic markers to identify novel incursions of the myrtle rust pathogen Austropuccinia psidii

This study develops a diagnostic method using mating-type HD locus alleles to identify new incursions of the myrtle rust pathogen Austropuccinia psidii.

ALDH1A3-acetaldehyde metabolism potentiates transcriptionalheterogeneity in melanoma

This study shows ALDH1A3 and ACSS2 coordinate acetaldehyde-acetyl-CoA metabolism with histone acetylation in melanoma, contributing to transcriptional heterogeneity and drug resistance.

Prospective Fecal Microbiomics Biomarkers for Chronic Wasting Disease

This study identifies fecal microbiome and metabolomics biomarkers that can differentiate CWD-positive from CWD-negative deer with 70% accuracy.

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

Multiplexed effector screening for recognition by endogenous resistance genes using positive defense reporters in wheat protoplasts

This paper develops a wheat protoplast assay for efficient screening of Avr/R gene interactions, enabling multiplexed testing and improved identification of defense responses.

Host's genetic background determines the outcome of reciprocal faecal transplantation on life-history traits and microbiome composition

This study shows that host genotype affects microbiome composition and life-history traits through reciprocal faecal transplantation in wood tiger moths.

Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

This paper develops human bone marrow organoids to model hematological malignancies and validate therapeutic targets.

Strain-level variation influences Methanothermococcus fitness in marine hydrothermal systems

The paper examines strain-level variation in Methanothermococcus across hydrothermal vents, finding that some strains outcompete others and that accessory genes like nitrogen fixation and CRISPR/Cas do not always confer a fitness advantage.

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

This study quantifies gene-specific fitness effects of CHIP drivers over 12 years using longitudinal sequencing data and a new DIF filtering method, showing gene-specific differences can inform personalized clinical management.

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

The paper generates 24 induced pluripotent stem cell lines from members of the Lothian Birth Cohort 1936 to study cognitive ageing and neurodegenerative disease resilience.

An alternative AUG codon in segment 5 of the 2009 pandemic influenza A virus is a swine-derived virulence motif

The paper identifies an alternative AUG codon in the 2009 pandemic influenza A virus as a virulence factor contributing to pathogenicity in swine and humans.