Alpha-ketoglutarate augments prolyl hydroxylase-2 mediated inactivation of phosphorylated-Akt to inhibit induced-thrombosis and inflammation
N. M. Shrimali, S. Agarwal, S. Kaur, S. Bhattacharya, S. Bhattacharyya, J. T. Prchal, P. Guchhait
This study shows that alpha-ketoglutarate inhibits Akt-driven thrombosis and inflammation by enhancing PHD2 activity and reducing pAkt1 levels in platelets and leukocytes.
bioRxiv · Jun 11, 2021Pathology