Inhibiting DDX3X triggers tumor-intrinsic type I interferon response and enhances anti-tumor immunity
H. Choi, J. Kwon, J. Sun, M. S. Cho, Y. Sun, J. L. Casey, J. Toretsky, C. Han
This study shows that inhibiting DDX3X in breast cancer cells increases type I interferon response and enhances anti-tumor immunity by promoting antigen presentation and T cell infiltration.
bioRxiv · Sep 9, 2020Cancer Biology