C. Han

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Clade-defining mutations in human H1N1 hemagglutinin protein from 2021-2023 have opposing effects on in vitro fitness and antigenic drift

This study identifies clade-defining mutations in H1N1 hemagglutinin that improve viral fitness but reduce neutralization by vaccine-induced antibodies, revealing an evolutionary trade-off between replication and immune evasion.

Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in Caenorhabditis elegans

This study identifies two neuroendocrine circuits in C. elegans where nervous system signaling to the gut bidirectionally regulates lifespan depending on life stage.

Genome-wide exploration of metabolic-based pyrethroid resistance mechanism in Helicoverpa armigera

This study identifies CYP3 subfamily gene variants and differential expression of detoxification enzymes as key factors in deltamethrin resistance in Helicoverpa armigera, rather than target site mutations.

Regulation of blood pressure by METTL3 via RUNX1b-eNOS pathway in endothelial cells

This study shows METTL3 reduces blood pressure by stabilizing RUNX1b mRNA via m6A modification, increasing eNOS expression in endothelial cells.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

Percutaneous Intramyocardial Septal Cryoablation: A Canine Model with 6 months Follow-up

This study establishes a canine model for echocardiography-guided percutaneous intramyocardial septal cryoablation and shows its safety and feasibility in reducing interventricular septum.

Tumor-derived exosomal miR-222-3p induce cancer-associated fibroblasts activation to foster progression of renal cancer

This study shows that tumor-derived exosomal miR-222-3p activates fibroblasts to promote renal cancer progression by inducing metabolic changes and cytokine secretion.

Using artificial intelligence to document the hidden RNA virosphere

This study uses a deep learning algorithm to discover highly divergent RNA viruses in metatranscriptomes, identifying 161,979 potential species and 180 supergroups.

The novel roles of bovine milk-derived exosomes on skin anti-aging

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.

A novel purity analysis method of bovine milk-derived exosomes by two-dimensional high-performance liquid chromatography

This paper introduces a 2D-HPLC method for analyzing the purity of bovine milk-derived exosomes, showing improved accuracy, precision, and efficiency compared to existing methods.

An oral vaccine for SARS-CoV-2 RBD mRNA-bovine milk-derived exosomes induces a neutralizing antibody response in vivo

An oral mRNA vaccine using bovine milk-derived exosomes encoding SARS-CoV-2 RBD induces neutralizing antibodies in mice.

BysR, a LysR-type Pleiotropic Regulator, Controls Production of Occidiofungin by Activating the LuxR-type transcriptional regulator AmbR1 in Burkholderia sp. JP2-270

This paper identifies BysR as a LysR-type regulator that activates ambR1 to control occidiofungin production in Burkholderia sp. JP2-270 and reveals its broader regulatory role in metabolism and motility.

Introducing an argonaute-facilitated PCR platform

This paper introduces an argonaute-facilitated PCR platform that improves PCR sensitivity by using MejAgo to enhance guide DNA/template pairing, eliminating the need for an annealing step.

Rapid macropinocytic transfer of α-synuclein to lysosomes

This study shows alpha-synuclein fibrils are rapidly internalized via macropinocytosis and directed to lysosomes, with some transferred to neighboring cells.

Optogenetic operated probiotics to regulate host metabolism by mimicking enteroendocrine

The paper develops an optogenetic probiotics system to control enteroendocrine hormone secretion in vivo, demonstrating improved glucose control in animal models.

MutS and DNA Function as a Clamp Loader for the MutL Sliding Clamp During Mismatch Repair

This study investigates how MutS and DNA interact to load the MutL sliding clamp during mismatch repair, revealing distinct mechanisms from replication clamp loaders.

Gene structure-based homology search identifies highly divergent putative effector gene family

The paper identifies putative homologs of rapidly evolving bicycle genes in multiple aphid species using gene structure features, finding strong expression in salivary glands associated with plant manipulation.

DNA metabarcoding Uncover the Diet of Subterranean Rodents in China

This study uses DNA metabarcoding to analyze the diet of two zokor species in China, revealing their reliance on perennial herb roots and identifying key plant families and genera in their diet.

Limited variation between SARS-CoV-2-infected individuals in domain specificity and relative potency of the antibody response against the spike glycoprotein

The paper analyzes antibody responses in SARS-CoV-2-infected individuals, finding limited variation in domain specificity and relative neutralization potency across subjects.

Combining Multi-Dimensional Molecular Fingerprints to Predict hERG Cardiotoxicity of Compounds

This study develops a molecular dynamic fingerprint (MDFP) and combines it with traditional fingerprints to predict hERG cardiotoxicity, achieving higher accuracy than single-fingerprint models.

Controlling Cellular Arrangements via Stretched Bioprinting

This paper introduces a bioprinting method that controls cellular orientation through stretching, enabling aligned myofiber formation and effective tissue repair in vivo.

The fusion peptide proximal region of the HIV-1 envelope glycoproteins regulates exposure of immunogenic epitopes at the trimer base

The paper examines how alanine substitutions in the HIV-1 Env FPPR region affect trimer conformation and epitope exposure, revealing weak antibody pressures shaping Env evolution.

Diet unmasks genetic variants that regulate lifespan in outbred Drosophila

This study identifies lifespan-altering genetic variants in Drosophila under different diets, showing context-dependent effects and genotype-by-environment interactions.

Inhibiting DDX3X triggers tumor-intrinsic type I interferon response and enhances anti-tumor immunity

This study shows that inhibiting DDX3X in breast cancer cells increases type I interferon response and enhances anti-tumor immunity by promoting antigen presentation and T cell infiltration.

Phagocytosis and self-destruction execute dendrite degeneration of Drosophila sensory neurons at distinct levels of NAD+ reduction

This study shows that NAD+ reduction triggers PS exposure and self-destruction in Drosophila sensory dendrites, with phagocytosis driving degeneration and Axed acting in parallel with PS-induced phagocytosis.

Ultra-sensitive nanozyme-based chemiluminescence paper test for rapid diagnosis of SARS-CoV-2 infection

This paper develops a rapid, sensitive, and low-cost nanozyme-based chemiluminescence paper test for SARS-CoV-2 antigen detection with results in under 16 minutes.

Reconstruction of Bone Defect Based on the Fusion of Osteoblasts and MSM/HA/PLGA Porous Scaffolds

This study develops and evaluates porous scaffolds combining HA, PLGA, and MSM for bone defect reconstruction, showing improved cell adhesion, proliferation, and drug release properties.

Quantitative LCMS for ceramides/dihydroceramides: pregnancy baseline biomarkers and potential metabolic messengers

This paper develops and validates an LC/MS/MS method to quantify ceramides and dihydroceramides in human serum, revealing unique gestational patterns during pregnancy.