J. Kwon

TMEM33 deletion potentiates anti-tumor CD8+ T cell immunity

This study shows TMEM33 limits progenitor-exhausted CD8+ T cells, enhances anti-tumor responses, and correlates with improved survival in melanoma patients.

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.

Age-dependent RGS5 loss in pericytes induces cardiac dysfunction and fibrosis in the heart

This study shows that loss of RGS5 in pericytes with age leads to cardiac dysfunction and fibrosis by altering pericyte function and activating fibroblasts.

The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix

This paper shows that the MRL mouse strain's extracellular matrix promotes muscle regeneration in muscular dystrophy by reducing fibrosis and enhancing myoblast growth.

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

This study shows that the agr quorum-sensing system in Staphylococcus aureus primes the bacteria to resist oxidative stress by controlling reactive oxygen species, even when the system is not actively activated.

Measurement of Oxidative Stress in Huh-7 Cell Line to Determine the Effectiveness of PNPLA3 Targeted Gene Therapy for Mitigation of Lipid and Alcohol Induced Oxidative Stress in the Liver

This study assesses the effectiveness of PNPLA3 gene therapy in reducing oxidative stress in Huh-7 cells exposed to lipid and alcohol-induced stress.

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

VRK1 is required in VRK2-methylated cancers of the nervous system

The paper identifies VRK1 as a synthetic lethal target in VRK2-methylated nervous system cancers through CRISPR screens and functional studies.

Global Plant Extinction Risk Assessment Informs Novel Biodiversity Hotspots

This paper uses AI to predict extinction risk for all vascular plants and identifies new biodiversity hotspots for conservation.

CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies

This study identifies CREB5 as a key driver of resistance to androgen receptor targeting therapies by reprogramming nuclear interactions and activating TGFβ and Wnt signaling pathways.

A Combination Strategy of Solubility Enhancers for Effective Production of Soluble and Bioactive Human Enterokinase

This study develops a strategy using solubility enhancers to produce soluble and bioactive human enterokinase in bacteria.

Inhibiting DDX3X triggers tumor-intrinsic type I interferon response and enhances anti-tumor immunity

This study shows that inhibiting DDX3X in breast cancer cells increases type I interferon response and enhances anti-tumor immunity by promoting antigen presentation and T cell infiltration.

Pseudogene-mediated DNA demethylation leads to oncogene activation

This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.

Embedded Enzyme Nanoclusters Depolymerize Polyesters via Chain-End Mediated Processive Degradation

This paper demonstrates that enzyme nanoclusters can depolymerize polyesters via chain-end mediated processive degradation, enabling scalable bioactive plastics for efficient sorting.