B. Klink

Exploiting a metabolic vulnerability in brain tumour stem cells using a brain-penetrant drug with safe profile

This study shows that mubritinib targets brain tumour stem cells by inhibiting complex I of the electron transport chain, delays glioblastoma tumourigenesis, and is safe in mice.

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

This study characterizes the tumor microenvironment in glioblastoma patient-derived xenografts and patient tumors, revealing phenotypic heterogeneity in microglia and their functional adaptations.

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration

This study identifies RNA as a significant source of tumor-agnostic neoantigens, which correlate with T-cell infiltration in multiple cancer types.

TGF-beta promotes microtube formation in glioblastoma through Thrombospondin 1

This study identifies TGF-beta and TSP1 as key drivers of microtube formation in glioblastoma, showing their role in invasion and treatment resistance.

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine

This study shows that glioma PDOX models accurately represent patient tumors and can predict treatment responses in personalized medicine.

A stochastic model of metastatic bottleneck predicts patient outcome and therapy response

The paper develops a stochastic model of metastatic bottleneck to predict patient outcomes and therapy response, showing that interventions targeting the bottleneck are more effective than reducing overall tumor burden.

Patterns of tumor progression predict small and tissue-specific tumor-originating niches

The paper estimates the minimal number of tumor cells required for tumor formation in human tissues and proposes the existence of small, tissue-specific tumor-originating niches.