Author

J. Valton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

P. Duchateau· 3 shared L. Poirot· 2 shared S. Das· 2 shared A. Boyne· 1 shared a. Duclert· 1 shared A. Gouble· 1 shared A. Juillerat· 1 shared A. Leroy· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioengineering

P. Duchateau

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TALEN-mediated intron editing of HSPCs enables transgene expression restricted to the myeloid lineage

E. Seclen, J. C. Jang, A. O. Lawal, S. Pulicani, A. Boyne, D. Tkach, A. Juillerat, P. Duchateau, J. Valton

This paper edits introns of HSPCs to restrict transgene expression to the myeloid lineage, demonstrating efficacy in treating metabolic diseases and reaching the brain.

bioRxiv · Mar 5, 2024Bioengineering

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy.

S. Das, J. Valton, P. Duchateau, L. Poirot

This study develops FAP-targeted CAR-T cells to deplete stromal CAFs, enhancing tumor infiltration and anti-tumor activity in solid tumors.

bioRxiv · Feb 27, 2023 · PreprintCancer Biology

Endowing Universal CAR T-cell with Immune-Evasive Properties using TALEN-Gene Editing.

S. Jo, S. Das, A. Williams, A.-s. Chretien, T. Pagliardini, A. Leroy, j. postigo-fernandez, D. leclerre, B. jahangiri, i. chion-sotinel, A. Gouble, M. Dusseaux, r. Galetto, a. Duclert, E. Marcenaro, , J. Valton

This paper develops a novel CAR T-cell scaffold with immune-evasive properties to enable universal allogeneic CAR T-cell therapy.

bioRxiv · Dec 6, 2021Immunology