Cancer BiologybioRxivPreprint
Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy.
S. Das, J. Valton, P. Duchateau, L. Poirot
This study develops FAP-targeted CAR-T cells to deplete stromal CAFs, enhancing tumor infiltration and anti-tumor activity in solid tumors.
DOI 10.1101/2023.02.27.529938