L. Young

Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.

Cancer drug sensitivity prediction from routine histology images

This paper demonstrates using deep learning to predict cancer drug sensitivity from histology images and cell line data, identifying histological patterns linked to drug responses.

Data-Driven Modelling of Gene Expression States in Breast Cancer and their Prediction from Routine Whole Slide Images

The paper predicts gene expression states from whole slide images using a graph neural network and identifies co-expressing gene groups with clinical and therapeutic relevance.

Biodiversity shows unique responses to land-use change across regional biomes

This study identifies regional biomes as a better scale than biomes or realms alone to capture variation in biodiversity responses to land-use change, with consistent negative effects in tropical forests.

LDL Receptor-Related Protein 5 is a Selective Transporter for Unesterified Polyunsaturated Fatty Acids

This study identifies LRP5 as a selective transporter for unesterified PUFAs, showing its role in mTORC1 inhibition and protection against myocardial injury.

Modelling drug responses and evolutionary dynamics using triple negative breast cancer patient-derived xenografts

This paper uses TNBC patient-derived xenografts to model drug responses and evolutionary dynamics, revealing a novel mechanism of olaparib response and synergistic effects with salinomycin.

Past, present, and future of the Living Planet Index

The paper reviews the evolution of the Living Planet Index, its role in biodiversity monitoring, and its findings of a 68% global vertebrate population decline between 1970 and 2016.

Early life exposure to high fructose diet induces metabolic dysregulation associated with sex-specific cognitive impairment in adolescent rats.

This study shows that early life high fructose exposure in rats leads to metabolic dysregulation and male-specific cognitive impairments in adolescence.

3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration

This study identifies a 3D matrix adhesion complex involving β-PIX and Myo18A that drives invasive cell migration by coupling nuclear force transmission to protrusion dynamics.

Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging

This paper develops a PET probe for subtype-selective V1A receptor imaging in peripheral organs, showing high affinity and selectivity for V1A over other vasopressin receptors.

Improving COVID-19 Testing Efficiency using Guided Agglomerative Sampling

This paper proposes agglomerative sampling to improve testing efficiency for low-prevalence COVID-19 populations, achieving ~40% test savings in simulations.

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

This paper uses machine learning on whole-genome sequencing of plasma cell-free DNA to detect early-stage colorectal cancer with high sensitivity and specificity.

Can the location of a trophectoderm biopsy contribute to human blastocyst development ?

This study investigates how the location of a trophectoderm biopsy in human blastocysts affects their development, finding that biopsies near the inner cell mass improve blastocoel development.