J. Vollrath

This paper introduces a new CRBN construct for efficient binder discovery, showing it outperforms existing constructs in binding and production, and applies it to identify potent CRBN binders from a large compound library.

This study shows that CYP51 is not essential for T. cruzi epimastigote growth but is required for stress tolerance, as its disruption leads to sterol auxotrophy and sensitivity to elevated temperature.

This study shows that glutamine metabolism affects azole susceptibility in Trypanosoma cruzi amastigotes by influencing sterol biosynthesis and metabolic intermediates.