Author

H. J. Bailey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

W. W. Yue· 4 shared C. Strain-Damerell· 2 shared A. A. Wegener· 1 shared A. Basle· 1 shared A. Chaikuad· 1 shared A. Martelli· 1 shared B. Dimitrov· 1 shared B. Fowler· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersBiochemistry

W. W. Yue

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Author profile →

5 papers

Recent·Most cited

Engineering CRBN for rapid identification of next generation binders

H. J. Bailey, J. Eisert, J. Vollrath, E.-M. Leibrock, I. Kondratov, T. Matviyuk, N. Tolmachova, J. D. Langer, A. A. Wegener, F. J. Sorrell, I. Dikic

This paper introduces a new CRBN construct for efficient binder discovery, showing it outperforms existing constructs in binding and production, and applies it to identify potent CRBN binders from a large compound library.

bioRxiv · Jan 18, 2024 · PreprintBiophysics

Architecture and regulation of filamentous humancystathionine beta-synthase

T. J. McCorvie, H. J. Bailey, C. Strain-Damerell, A. Basle, W. W. Yue

This study uses cryo-electron microscopy to reveal how human CBS regulates activity through conformational changes in its regulatory domain.

bioRxiv · Feb 15, 2023Biochemistry

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism

G. A. Bezerra, W. R. Foster, H. J. Bailey, K. G. Hicks, S. W. Sauer, B. Dimitrov, J. G. Okun, J. Rutter, S. Koelker, W. W. Yue

This study presents the crystal structure of human DHTKD1 and a 3D reconstruction of the DLST inner core, revealing structural insights into lysine catabolism and potential drug targets.

bioRxiv · Jan 20, 2020Biochemistry

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

N. G. Fox, X. Yu, X. Feng, H. J. Bailey, A. Martelli, J. F. Nabhan, C. Strain-Damerell, C. Bulawa, W. W. Yue, S. Han

The paper determines the cryo-EM structure of the FXN-bound active human ISC biosynthesis complex, revealing how FXN activates NFS1 by removing zinc inhibition and stabilizing protein interfaces.

bioRxiv · Feb 28, 2019Biochemistry

Genetic, structural, and functional analysis of mutations causing methylmalonyl-CoA epimerase deficiency

K. Heuberger, H. J. Bailey, P. Burda, A. Chaikuad, E. Krysztofinska, T. Suormala, C. Buerer, S. Lutz, B. Fowler, D. S. Froese, W. W. Yue, M. R. Baumgartner

The paper identifies ten new patients with MCEE deficiency, analyzes mutations in the MCEE gene, and reveals structural and functional defects in the enzyme caused by these mutations.

bioRxiv · Nov 30, 2018Biochemistry