BiophysicsbioRxiv
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation
P. Juyoux, I. Galdadas, D. Gobbo…·M. W. Bowler
The paper determines the structure and activation mechanism of the MKK6-p38α complex using cryo-EM and MD simulations, revealing how phosphorylation and interactions drive MAPK specificity.
DOI 10.1126/science.add7859