BiochemistrybioRxiv
Age-related susceptibility to insulin resistance is due to a combination of CPT1B decline and lipid overload
M. A. Vieira-Lara, M. B. Dommerholt, W. Zhang…·B. M. Bakker
This study shows that age-related insulin resistance in mice is caused by both reduced CPT1B and lipid overload, not just mitochondrial dysfunction or diet alone.
DOI 10.1186/s12915-021-01082-5