Nucleoporin Nsp1 surveils the phase state of FG-Nups
T. A. Otto, T. Bergsma, M. Dekker…·L. L. Veenhoff
The paper shows that Nsp1 modulates FG-Nup phase separation and its loss mimics aging phenotypes in yeast.
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5 papers
Recent·Most cited
T. A. Otto, T. Bergsma, M. Dekker…·L. L. Veenhoff
The paper shows that Nsp1 modulates FG-Nup phase separation and its loss mimics aging phenotypes in yeast.
M. A. Vieira-Lara, A. C. Reijne, S. Koshian…·B. M. Bakker
This study shows that exercise improves age-related decline in insulin sensitivity in mice, but only when combined with a healthy diet.
M. S. Taylor, W. Connie, P. C. Fridy…·O. H. Yilmaz
This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.
M. F. Semmelink, H. Jafarinia, J. C. Wolters…·L. M. Veenhoff
This study shows polyPR directly affects nuclear transport via NTRs, while polyGA impacts cellular energy state, leading to similar transport defects as stress conditions.
M. A. Vieira-Lara, M. B. Dommerholt, W. Zhang…·B. M. Bakker
This study shows that age-related insulin resistance in mice is caused by both reduced CPT1B and lipid overload, not just mitochondrial dysfunction or diet alone.