Author

J. W. Raff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

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Research Focus:cell signaling & trafficking· 6 Organism:Drosophila· 4 Approach:experimental assay· 4 Approach:statistical model· 2 Research Focus:development & morphogenesis· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. Wainman· 4 shared S. Saurya· 4 shared M. G. Aydogan· 3 shared S.-S. Wong· 3 shared T. L. Steinacker· 3 shared F. Y. Zhou· 2 shared L. Gartenmann· 2 shared M. Mofatteh· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersCell Biology

A. Wainman

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6 papers

Recent·Most cited

Cdk/Cyclin activity helps set mitotic centrosome size by influencing the centrosome growth rate and growth period

S.-S. Wong, A. Wainman, S. Saurya, J. W. Raff

The paper shows that Cdk/Cyclin activity regulates mitotic centrosome size by modulating growth rate and period in Drosophila embryos.

bioRxiv · Apr 25, 2023 · PreprintCell Biology

A simple Turing reaction-diffusion model can explain how mother centrioles break symmetry to generate a single daughter

Z. W. Wilmott, A. Goriely, J. W. Raff

The paper proposes a Turing reaction-diffusion model to explain how PLK4 breaks symmetry to generate a single daughter centriole.

bioRxiv · Feb 2, 2023 · PreprintCell Biology

Centriole distal-end proteins CP110 and Cep97 influence centriole cartwheel growth at the proximal-end

M. G. Aydogan, L. E. Hankins, T. L. Steinacker, M. Mofatteh, S. Saurya, A. Wainman, S.-S. Wong, X. Lu, F. Y. Zhou, J. W. Raff

The paper shows that CP110 and Cep97 at the distal end of centrioles influence cartwheel growth at the proximal end through interactions with Plk4 oscillations.

Journal of Cell Science · Jul 20, 2022Peer-reviewedCell Biology

Centriole growth is not limited by a finite pool of components, but is limited by the Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL

T. L. Steinacker, S.-S. Wong, Z. A. Novak, S. Saurya, L. Gartenmann, E. J. H. van Houtum, J. R. Sayers, B. C. Lagerholm, J. W. Raff

The paper shows that centriole growth in Drosophila embryos is not limited by component availability but by Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL, which regulates growth timing.

bioRxiv · Feb 15, 2022Cell Biology

An autonomous oscillator times and executes centriole biogenesis

M. G. Aydogan, T. L. Steinacker, M. Mofatteh, L. Gartenmann, A. Wainman, S. Saurya, S. S. Wong, F. Y. Zhou, M. A. Boemo, J. W. Raff

The paper identifies an autonomous Plk4 oscillator at the base of growing centrioles in Drosophila embryos that times and sets centriole biogenesis duration, independent of the cell cycle.

bioRxiv · Mar 18, 2019 · PreprintCell Biology

A positive feedback loop drives centrosome maturation in flies

I. Alvarez Rodrigo, P. T. Conduit, J. Baumbach, Z. A. Novak, M. G. Aydogan, A. Wainman, J. W. Raff

The paper identifies a positive feedback loop involving Spd-2, Polo, and Cnn that drives centrosome maturation in flies by enabling scaffold expansion.

bioRxiv · Jul 31, 2018Cell Biology