F. Y. Zhou

This paper introduces 3D CyCIF, a method for high-plex 3D profiling of cell states and immune niches in human tumors, revealing detailed spatial interactions and cytokine niches previously unattainable in thin sections.

The paper introduces a mesoscopic oblique plane microscope for whole-organism imaging with high speed and subcellular resolution, demonstrating its application in zebrafish vasculature and blood flow analysis.

The paper shows that CP110 and Cep97 at the distal end of centrioles influence cartwheel growth at the proximal end through interactions with Plk4 oscillations.

This study identifies a ZBP1-RIPK1-RIPK3 pathway that promotes SARS-CoV-2-induced cytokine expression through inflammatory signaling independent of cell death.

The paper identifies an autonomous Plk4 oscillator at the base of growing centrioles in Drosophila embryos that times and sets centriole biogenesis duration, independent of the cell cycle.