P. T. Conduit

The paper investigates γ-tubulin complex recruitment mechanisms at mitotic centrosomes in Drosophila, showing that Spd-2 and Cnn use different pathways to nucleate microtubules, with implications for centrosome robustness and microtubule dynamics.

The paper shows daughter centrioles in Drosophila embryos assemble preferentially toward the nuclear envelope, suggesting non-centrosomal cues guide duplication site establishment.

This study shows that γ-TuRCs are essential for directional microtubule nucleation from the Golgi in Drosophila neurons, supporting a model of asymmetric microtubule growth and guidance.

The paper identifies an auto-inhibition domain in Cnn that regulates binding to γ-TuRCs, preventing ectopic microtubule nucleation and cell division defects.

The paper shows that microtubules originate asymmetrically at the Golgi in Drosophila neurons and are guided by Kinesin-2 to maintain axonal polarity while excluding dendrites.

The paper identifies a positive feedback loop involving Spd-2, Polo, and Cnn that drives centrosome maturation in flies by enabling scaffold expansion.