S. Hammerschmidt

The role of pneumococcal extracellular vesicles on the pathophysiology of the kidney disease Hemolytic Uremic Syndrome

This paper investigates the role of pneumococcal extracellular vesicles in the pathogenesis of hemolytic uremic syndrome and identifies their cargo and effects on host cells.

Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors

This study shows that competence in Streptococcus pneumoniae is crucial for virulence by increasing surface exposure of virulence factors and providing resistance to fratricide.

The choline-binding proteins PspA, PspC and LytA of Streptococcus pneumoniae and their role on host cellular adhesion and damage

This study investigates the role of choline-binding proteins PspA, PspC, and LytA in Streptococcus pneumoniae adhesion and pathogenicity using imaging and functional assays.

Alpha-hemolysin of Staphylococcus aureus impairs thrombus formation

This study shows that Staphylococcus aureus alpha-hemolysin activates and then damages platelets, impairing thrombus formation and stability, and is not neutralized by polyvalent immunoglobulins.

A novel innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins

The paper identifies a novel innate pathogen sensing strategy through ubiquitination of bacterial surface proteins, revealing a conserved mechanism for pathogen detection and clearance.

A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae

This paper develops a synthetic glycoconjugate vaccine that combines pneumococcal proteins with a defined oligosaccharide to provide broad protection against multiple serotypes of Streptococcus pneumoniae in animal models.

Same, Same, but Different: Molecular Analyses of Streptococcus pneumoniae Immune Evasion Proteins Identifies new Domains and Reveals Structural Differences between PspC and Hic Variants

The paper analyzes PspC and Hic proteins from Streptococcus pneumoniae to identify new domains and structural differences, improving understanding of their immune evasion mechanisms and vaccine design.

Pneumococcal metabolic adaptation and colonization is regulated by the two-component regulatory system 08

This study identifies the role of TCS08 in regulating pneumococcal gene expression related to metabolism and colonization, showing strain-dependent effects on virulence in infection models.