Author

A. Simonsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 2 Cancer Biology· 1 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 7 Approach:experimental assay· 7 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:ecology & biodiversity· 2 Organism:plant (other)· 2

Frequent Co-Authors

A. H. Lystad· 4 shared S. Singh· 3 shared B. J. Mathai· 2 shared L. Trachsel-Moncho· 2 shared M. Frederickson· 2 shared M. J. Munson· 2 shared A. F. Lopez-Clavijo· 1 shared A. Hassan· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersCell Biology

A. H. Lystad

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics

L. Trachsel-Moncho, C. Veroni, B. J. Mathai, A. Lapao, S. Singh, N. T. Asp, S. W. Schultz, S. Pankiv, A. Simonsen

This study identifies SNX10 as a negative regulator of piecemeal mitophagy and mitochondrial bioenergetics, showing its role in modulating mitochondrial homeostasis and cell survival.

bioRxiv · May 15, 2024Cell Biology

Generalized mutualisms promote range expansion in both plant and ant partners

P. Nathan, B. Guenard, E. P. Economo, A. Simonsen, M. Frederickson

The paper analyzes global data on mutualistic traits and species ranges to show that generalized mutualisms enhance the spread of legumes and ants beyond their native ranges, while specialized mutualisms hinder it.

bioRxiv · Apr 12, 2023 · PreprintEcology

Symbiosis with rhizobia limits range expansion only in polyploid legumes

Z. Parshuram, T. L. Harrison, A. Simonsen, J. R. Stinchcombe, M. Frederickson

The paper examines how symbiosis with rhizobia and polyploidy affect range expansion in legumes, finding that rhizobia symbiosis limits expansion only in polyploids.

bioRxiv · Mar 1, 2022 · PreprintEvolutionary Biology

GRAMD1C promotes autophagy initiation and mitochondrial bioenergetics through regulation of ER-mitochondria cholesterol transport

M. Y. W. Ng, C. Charsou, A. S. D. S. Lapao, S. Singh, L. Trachsel-Moncho, S. Nakken, M. J. Munson, A. Simonsen

This study identifies GRAMD1C as a negative regulator of starvation-induced autophagy and mitochondrial function through cholesterol transport between the ER and mitochondria.

bioRxiv · Aug 4, 2021 · PreprintBiochemistry

Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway

A. M. Rahman, A. S. T. Engelsen, S. Sarowar, C. Bindesboll, E. Birkeland, M. L. Lotsberg, S. Knappskog, A. Simonsen, M. Chekenya

This study shows bortezomib blocks temozolomide-induced autophagy in GBM cells via an ATG5-dependent pathway, enhancing TMZ efficacy.

bioRxiv · Dec 20, 2020Cancer Biology

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

M. J. Munson, B. J. Mathai, L. Trachsel, M. Yoke Wui Ng, L. Rodriguez de la Ballina, S. Schultz, Y. Aman, A. H. Lystad, S. Singh, S. Singh, J. Wesche, E. F. Fang, A. Simonsen

This study identifies GAK and PRKCD as positive regulators of PRKN-independent mitophagy through genetic screening and functional analysis in vitro and in vivo.

bioRxiv · Nov 5, 2020Cell Biology

The Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy

D. Corkery, A. Nadeem, K. M. Aung, A. Hassan, T. Liu, R. Cervantes-Rivera, A. H. Lystad, H. Wang, K. Persson, A. Puhar, A. Simonsen, B. E. Uhlin, S. N. Wai, Y. Wu

This study shows that Vibrio cholerae toxin MakA induces noncanonical autophagy, which inhibits canonical autophagy and immune responses like IL-1β secretion.

bioRxiv · Jul 7, 2020Cell Biology

Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine

J. Durgan, A. H. Lystad, K. Sloan, S. R. Carlsson, M. I. Wilson, E. Marcassa, R. Ulferts, J. Webster, A. F. Lopez-Clavijo, M. J. Wakelam, R. Beale, A. Simonsen, D. Oxley, O. Florey

This study shows that during non-canonical autophagy, ATG8 proteins are conjugated to phosphatidylserine instead of phosphatidylethanolamine, revealing a distinct lipidation mechanism.

bioRxiv · May 14, 2020Cell Biology

TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease

L. Herhaus, R. M. Bhaskara, A. H. Lystad, A. Simonsen, G. Hummer, I. Dikic

The paper shows TBK1 phosphorylates LC3C and GABARAP-L2, preventing their removal by ATG4 and ensuring proper autophagosome formation.

bioRxiv · May 10, 2019Biochemistry