J. Z. Sexton

This paper introduces a high-throughput microfluidic liver chip system using human liver organoids to model drug-induced liver injury with improved sensitivity and prolonged drug exposure capabilities.

The paper uses imaging-based screening to identify compounds that inhibit hyphal transition in C. albicans, identifying eIF3 as a target of NSC 697923.

This study identifies four nanomolar inhibitors of Dengue Virus replication using high-content screening and a viral pseudotime model.

The paper evaluates Cell Painting assay performance across different imaging systems, finding compatibility and identifying optimal settings for each.

This study evaluates niclosamide's limitations as a COVID-19 treatment and identifies analogs with improved potency and reduced toxicity.

This study identifies ARF6 as a host factor critical for SARS-CoV-2 entry and infection in vitro, showing its importance across different cell models.

This paper develops a simplified protocol for infecting 3D-human intestinal enteroids with human norovirus, showing improved infection efficiency and host response analysis.

This study evaluates human liver organoids for DILI risk prediction using high-throughput screening and a liver-on-chip system, showing enhanced predictive capacity and physiological relevance.

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

This study shows that knocking out Lyplal1 in mice leads to sex-specific protection against diet-induced obesity, mirroring human genetic findings.