Author

C. Mirabelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 8 Research Focus:drug response / drug discovery· 5 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. E. Wobus· 8 shared J. Z. Sexton· 4 shared J. Neyts· 3 shared J. W. Wotring· 3 shared B. T. Emmer· 2 shared C. J. Zhang· 2 shared E. J. Sherman· 2 shared K. Lanko· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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8 shared papersMicrobiology

C. E. Wobus

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Author profile →

11 papers

Recent·Most cited

Type I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection

J. B. Cunha, K. Leix, E. J. Sherman, C. Mirabelli, A. A. Kennedy, A. S. Lauring, A. W. Tai, C. E. Wobus, B. T. Emmer

This study identifies type I interferon signaling as inducing a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection, which may impair alveolar regeneration.

bioRxiv · Feb 28, 2023 · PreprintMicrobiology

In Vitro Evaluation and Mitigation of Niclosamide's Liabilities as a COVID-19 Treatment.

J. W. Wotring, S. M. McCarty, K. Shafiq, C. J. Zhang, T. Nguyen, S. R. Meyer, R. Fursmidt, C. Mirabelli, M. C. Clasby, C. E. Wobus, M. J. O'Meara, J. Z. Sexton

This study evaluates niclosamide's limitations as a COVID-19 treatment and identifies analogs with improved potency and reduced toxicity.

bioRxiv · Jun 24, 2022Microbiology

ARF6 is a host factor for SARS-CoV-2 infection in vitro

C. Mirabelli, E. J. Sherman, J. Bragazzi Cunha, J. W. Wotring, J. El Saghir, J. Harder, J. Z. Sexton, B. T. Emmer, C. E. Wobus

This study identifies ARF6 as a host factor critical for SARS-CoV-2 entry and infection in vitro, showing its importance across different cell models.

bioRxiv · Jun 9, 2022 · PreprintMicrobiology

Human norovirus efficiently replicates in differentiated 3D-human intestinal enteroids

C. Mirabelli, N. Santos-Ferreira, M. G. Gillilland, R. J. Cieza, J. Colacino, J. Z. Sexton, S. Taube, J. Rocha-Pereira, C. E. Wobus

This paper develops a simplified protocol for infecting 3D-human intestinal enteroids with human norovirus, showing improved infection efficiency and host response analysis.

bioRxiv · Jun 9, 2022Microbiology

Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19

C. Mirabelli, J. W. Wotring, C. J. Zhang, S. M. McCarty, R. Fursmidt, T. Frum, N. S. Kadambi, A. T. Amin, T. R. O'Meara, C. D. Pretto-Kernahan, J. R. Spence, J. Huang, K. D. Alysandratos, D. N. Kotton, S. K. Handelman, , J. Z. Sexton

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

Proceedings of the National Academy of Sciences · Aug 19, 2021Peer-reviewedCell Biology

Host-virus chimeric events in SARS-CoV2 infected cells are infrequent and artifactual

B. Yan, S. Chakravorty, C. Mirabelli, L. Wang, J. L. Trujillo-Ochoa, D. Chauss, D. Kumar, M. S. Lionakis, M. R. Olson, C. E. Wobus, B. Afzali, M. Kazemian

This study investigates host-virus chimeric (HVC) events in SARS-CoV2 RNA-seq data and finds they are rare and likely artifacts, not evidence of viral integration.

Journal of Virology · Jul 12, 2021Peer-reviewedMicrobiology

Human norovirus infection of primary B cells triggers immune activation in vitro

C. Mirabelli, M. K. Jones, V. Young, A. Kolawole, I. Owusu, M. Shan, B. H. Abuaita, I. Grigorova, S. K. Lundy, C. A. Lyssiotis, V. K. Ward, S. M. Karst, C. E. Wobus

This study shows human norovirus infects primary B cells, induces functional changes, and the NS1 protein affects B cell proliferation and metabolism in vitro.

bioRxiv · May 14, 2021 · PreprintMicrobiology

Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species

K. Lanko, L. Sun, M. Froeyen, P. Leyssen, L. Delang, C. Mirabelli, J. Neyts

The paper identifies mutations in picornaviruses that confer resistance to vapendavir, including both pocket and non-pocket mutations, and shows some mutations require drug presence for viral replication.

bioRxiv · Jul 16, 2020Microbiology

A Novel Small Animal Model of Norovirus Diarrhea

A. N. Roth, E. W. Helm, C. Mirabelli, E. Kirsche, J. Smith, L. B. Eurell, S. Ghosh, N. Altan-Bonnet, C. E. Wobus, S. M. Karst

This study identifies a murine norovirus that causes self-resolving diarrhea in neonatal mice without systemic disease, mirroring human norovirus infection and establishing a new animal model.

bioRxiv · Mar 19, 2020 · PreprintMicrobiology

Assessing the in vitro resistance development in Enterovirus 71 in the context of combination antiviral treatment

K. Lanko, C. Shi, S. Patil, L. Delang, J. Matthijnssens, C. Mirabelli, J. Neyts

This study evaluates how combining antivirals with different mechanisms delays resistance development in EV-A71 to pirodavir.

bioRxiv · Feb 10, 2020 · PreprintMicrobiology

Differential Antiviral Activities of RSV Inhibitors in Human Airway Epithelium

C. Mirabelli, M. Jaspers, M. Boon, M. Jorissen, M. Koukni, D. Bardiot, P. Chaltin, A. Marchand, J. Neyts, D. Jochmans

This study evaluates the antiviral efficacy of RSV inhibitors in a 3D-human airway epithelium model, showing that replication inhibitors are more effective than fusion inhibitors even when treatment is delayed.

bioRxiv · Jan 19, 2018Microbiology