Author

J. Z. Sheng

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. Barrera· 1 shared C. V. Nicchitta· 1 shared H. X. Ang· 1 shared I. C. McDowell· 1 shared J. Lin· 1 shared K. C. Wood· 1 shared L. C. Bartelt· 1 shared N. Sutiman· 1 shared

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2021-2021 · peak 1/yr

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1 shared paperCancer Biology

A. Barrera

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintMar 3, 2021

Cooperative regulation of coupled oncoprotein translation and stability in triple-negative breast cancer by EGFR and CDK12

H. X. Ang, N. Sutiman, X. L. Deng…·K. C. Wood

The paper identifies CDK12 inhibition as a strategy to enhance EGFR blockade efficacy in TNBC by targeting translation and stability of oncoproteins like MYC through 4E-BP1 and CCR4-NOT complex.

DOI 10.1101/2021.03.03.433762

humanbulk RNA-seq

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