Opposite regulation of glycogen metabolism by cAMP produced in the cytosol and at the plasma membrane
A. J. Verhoeven, P. F. V. Bizerra, E. H. Gilglioni, S. Go, H. L. Li, R. P. J. O. Elferink, J.-C. Chang
This study shows that cAMP produced at the plasma membrane promotes glycogen breakdown, while cAMP produced in the cytosol inhibits it, highlighting the role of cAMP microdomain organization in glycogen metabolism.
bioRxiv · Sep 1, 2022 · PreprintBiochemistry