S. Noguchi

The gut lactic acid bacteria metabolite, 10-oxo-cis-6,trans-11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signaling

This study identifies 10-oxo-cis-6,trans-11-octadecadienoic acid as an anti-inflammatory metabolite that suppresses colitis in mice via NRF2 pathway activation and GPCR signaling.

Kaempferol suppresses the activation of mast cells by modulating the expression of FcϵRI and SHIP1

This study shows kaempferol suppresses mast cell activation by reducing FcεRI surface expression and increasing SHIP1 levels, independent of transcription and translation.

Imaging-based evaluation of pathogenicity by novel DNM2 variants associated with centronuclear myopathy

The paper evaluates the pathogenicity of novel DNM2 variants associated with centronuclear myopathy using an in cellulo imaging assay of T-tubule-like structures.

Lysosomal microautophagic pathway links proteostasis to protein aggregation disease

This study identifies SIDT2 as a mediator of microautophagy that delivers cytosolic proteins into lysosomes, linking proteostasis to protein aggregation disease.

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances reprogramming to epithelial lineages

This study identifies OVOL2 as a key factor that induces mesenchymal-to-epithelial transition in fibroblasts and enhances reprogramming to epithelial lineages.