Author

J.-H. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:imaging· 4 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Ekman· 4 shared C. A. Larabell· 3 shared C. Larabell· 3 shared G. McDermott· 2 shared M. A. LeGros· 2 shared V. Weinhardt· 2 shared A. Briner· 1 shared A. D. Gitler· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersCell Biology

A. Ekman

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Progression of herpesvirus infection remodels mitochondrial organization and metabolism

S. Leclerc, A. Gupta, V. Ruokolainen, J.-H. Chen, K. Kunnas, A. Ekman, H. Niskanen, I. Belevich, H. Vihinen, P. Turkki, A. Perez-Berna, S. Kapishnikov, E. Mäntylä, M. Harkiolaki, E. Dufour, , M. Vihinen-Ranta

This study shows how herpesvirus infection alters mitochondrial structure and metabolism during infection progression.

bioRxiv · Nov 16, 2023 · PreprintMicrobiology

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

S. Boeynaems, X. R. Ma, V. Yeong, G. M. Ginell, J.-H. Chen, J. A. Blum, L. Nakayama, A. Sanyal, A. Briner, D. Van Haver, J. Pauwels, A. Ekman, H. B. Schmidt, K. Sundararajan, L. Porta, , A. D. Gitler

The paper identifies a common toxic mechanism in positively charged peptides across species and develops a machine learning tool to detect it.

bioRxiv · Mar 9, 2023 · PreprintCell Biology

An ESCRT-dependent pathway of Nuclear and Cytoplasmic Spatial PQC is coordinated at Nuclear Vacuolar Junctions

E. M. Sontag, F. Morales-Polanco, J.-H. Chen, G. McDermott, P. T. Dolan, D. R. Gestaut, M. A. LeGros, C. Larabell, J. Frydman

The paper identifies an ESCRT-dependent pathway that coordinates nuclear and cytoplasmic protein quality control (PQC) at nuclear-vacuolar junctions, enabling vacuolar clearance of misfolded proteins.

bioRxiv · Dec 1, 2022 · PreprintBiochemistry

Emergent Actin Flows Explain Diverse Parasite Gliding Modes

C. L. Hueschen, L.-a. Segev Zarko, J.-H. Chen, M. A. LeGros, C. A. Larabell, J. C. Boothroyd, R. Phillips, A. R. Dunn

This study uses single-molecule imaging and modeling to show that F-actin flows in parasites self-organize to produce diverse gliding motility modes.

bioRxiv · Jun 8, 2022Biophysics

Extending of imaging volume in soft x-ray tomography

A. Ekman, J.-H. Chen, B. Vanslembrouck, C. A. Larabell, M. A. Le Gros, V. Weinhardt

This paper extends the imaging volume of soft x-ray tomography from 10 to 18 micrometers by developing a new theoretical and experimental framework.

bioRxiv · May 11, 2022Cell Biology

Characterization of dynamic age-dependent changes and driver microbes in primate gut microbiota during host's development and healthy aging via captive crab-eating macaque model

Z.-Y. Wei, J.-H. Rao, M.-T. Tang, G.-A. Zhao, Q.-C. Li, L.-M. Wu, S.-Q. Liu, B.-H. Li, B.-Q. Xiao, X.-Y. Liu, J.-H. Chen

This study characterizes age-dependent changes in primate gut microbiota using crab-eating macaques, identifying key driver microbes and their role in host development and aging.

bioRxiv · Mar 30, 2020 · PreprintMicrobiology

PSF correction in soft x-ray tomography

A. Ekman, V. Weinhardt, J.-H. Chen, G. McDermott, M. Le Gros, C. Larabell

The paper introduces a linear model for soft x-ray tomography that incorporates the 3D PSF to improve reconstruction using iterative schemes, validated on simulated and experimental data.

bioRxiv · Feb 5, 2018Cell Biology