NeurosciencebioRxivPreprint
Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model
DOI 10.64898/2025.12.10.693468
Author
Gladstone Institutes
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Min Joo Kim, Jessica R. Blumenfeld, Yaqiao Li…·Yadong Huang
This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.
Jessica R. Blumenfeld, Yaqiao Li, Min Joo Kim…·Yadong Huang
This study shows neuronal APOE4 alone can drive tau pathology, neurodegeneration, and neuroinflammation in a mouse model, similar to a human APOE4 knock-in model.