Author

Kaylie Suan

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jessica R. BlumenfeldiD· 4 shared Yadong HuangiD· 4 shared Yanxia Hao· 4 shared Claire Ellis· 3 shared David M. ShostakiD· 3 shared Jeremy Nguyen· 3 shared Leon Yao· 3 shared Min Joo KimiD· 3 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Jessica R. BlumenfeldORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintDec 13, 2025

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model

Oscar Yip, Leon Yao, Jessica R. Blumenfeld…·Yadong Huang

DOI 10.64898/2025.12.10.693468

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 9, 2025

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease

Min Joo Kim, Jessica R. Blumenfeld, Yaqiao Li…·Yadong Huang

This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

BioinformaticsbioRxivPreprintDec 8, 2025

Tri-AD: Hippocampal cell-type-specific responses to age, sex and APOE genotype

Yaqiao Li, Yanxia Hao, Carlota Pereda Serras…·Marina Sirota

The paper investigates how age, sex, and APOE genotype affect hippocampal cell-type-specific gene expression and communication in mice, revealing sex-divergent effects of APOE4.

DOI 10.64898/2025.12.03.691944

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 25, 2025

Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer's disease mouse model

Jessica R. Blumenfeld, Yaqiao Li, Min Joo Kim…·Yadong Huang

This study shows neuronal APOE4 alone can drive tau pathology, neurodegeneration, and neuroinflammation in a mouse model, similar to a human APOE4 knock-in model.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky