Cell BiologyeNeuroPeer-reviewed
Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimers disease mouse model
Alex Orlowski, Joseph Karippaparambil, Jean‐Michel Paumier…·Swetha Gowrishankar
The paper shows that loss of AP-4 complex function causes axonal lysosome buildup, which worsens amyloid plaque pathology and gliosis in an Alzheimer's disease mouse model.
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