PhysiologyHeart RhythmPeer-reviewed
Myocardial STIM1 deficiency triggers mitochondrial fission to impair electrophysiological function and exacerbate post-MI remodeling
Marine Cacheux, Juan Velasco, Jonathan M. Granger…·Fadi G. Akar
This study shows that reducing STIM1 in cardiomyocytes causes mitochondrial fragmentation and metabolic changes, leading to electrical instability and worsened heart function after a heart attack.
DOI 10.1016/j.hrthm.2026.04.030