Fadi G. Akar

This study shows that reducing STIM1 in cardiomyocytes causes mitochondrial fragmentation and metabolic changes, leading to electrical instability and worsened heart function after a heart attack.

This paper evaluates 99mTc-(HE)-(GPO) as a radiotracer for detecting collagen turnover in myocardial infarction, showing higher uptake in infarct zones and specificity for denatured collagen.

This study investigates the role of endothelial Rho kinase (ROCK1/2) in vascular integrity and angiogenesis, finding that their loss leads to vascular defects and lethality.

This study shows FGF13 regulates Cx43 trafficking and cardiac impulse propagation without involving voltage-gated sodium channels.

This study shows that AMPK activation by high-fat diet reduces arrhythmia risk by improving cardiac electrophysiology and mitochondrial function.

This study shows that desmoplakin loss causes PKC-dependent sarcomere shortening and contractile dysfunction in cardiomyocytes, leading to heart failure.

This study shows that atrial AMPK deletion shifts metabolism from fatty acid oxidation to pyruvate oxidation and disrupts metabolic pathways, contributing to atrial remodeling and arrhythmia.

The paper applies renewal theory to model phase singularity dynamics in cardiac fibrillation across species, finding exponential inter-event time distributions with consistent rate parameters.