Pharmacology & ToxicologybioRxivPreprint
Submembrane geography dictates GPCR signalling compartmentation and physiological function
Alexander Froese, Bing Qi, Miao Feng…·Viacheslav Nikolaev
This study shows that GPCR signaling varies based on submembrane location, with different functional outcomes in cardiomyocytes, and introduces submembrane-specific beta-blockers that target specific nanodomains.