Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells
Ting Zhao, Lingli He, Lai Ping Wong, Shenglin Mei, Jun Xia, Yanxin Xu, Jonathan G. Van Vranken, Michael C. Mazzola, Lei Chen, Catherine Rhee, Tiancheng Fang, Tsuyoshi Fukushima, Leanne C. Sayles, Matthew Diaz, J. Alex B. Gibbons, , David T. Scadden
The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.
bioRxiv · Apr 25, 2025 · PreprintCancer Biology