Lei Chen

Intrinsic fluctuations modulate thalamic gating during the emergence of human conscious perception

This study shows that intrinsic thalamic fluctuations before stimulus onset modulate conscious perception by compensating for stimulus strength and enabling efficient information processing.

Pulmonary colonization of Candida albicans drives breast cancer lung metastasis via candidalysin

This study shows that Candida albicans colonization in the lungs promotes breast cancer metastasis by activating mast cells and creating an immunosuppressive environment.

Structure-aware deep learning predicts influenza antigenicity and guides vaccine strain recommendation

This paper introduces Vir3D, a structure-aware deep learning model that predicts influenza antigenicity and improves vaccine strain selection by incorporating 3D structural information from amino acid sequences.

RNA Architecture Underlies Discontinuous Transcription and Evolution of Coronavirus

This study identifies RNA-RNA interactions and non-canonical sgRNAs in coronaviruses, revealing their role in transcription regulation and immune evasion.

Developing a Multimodal miR-15a Mimic to Overcome PARP Inhibitor Resistance in Epithelial Ovarian Cancer

This paper develops a multimodal miR-15a mimic to overcome PARP inhibitor resistance in ovarian cancer, showing synergy with olaparib and antitumor efficacy.

Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

The study on the impact of indoleacetic acid on enhancing the ability of the rumen's original microecology to degrade aflatoxin B1.

This study investigates how indoleacetic acid (IAA) enhances the rumen microecology's ability to degrade aflatoxin B1, showing improved degradation rates and microbial stability.

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

The paper identifies recurrently deregulated lncRNAs in HCC and PVTT samples, linking them to metastasis and prognosis using multi-omics data.