Cell BiologybioRxiv
Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages
E. D. Muse, S. Yu, C. R. Edillor…·C. K. Glass
This study shows that desmosterol and its mimetics selectively activate LXR in macrophages without inducing SREBP1c-mediated hypertriglyceridemia, unlike conventional LXR agonists.