Cancer BiologybioRxivPreprint
BET inhibitors synergize with anti-PD1 by rescuing TCF1+ progenitor exhausted CD8+ T cells in Acute Myeloid Leukemia
K. A. Romine, H. J. Cho, Y. Kosaka…·E. F. Lind
This study shows BET inhibitors enhance anti-PD1 therapy by reversing T cell exhaustion in AML, increasing CD8+ T cell function and reducing leukemia cells.
DOI 10.1101/2021.08.04.455147