J. Scott

Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators

This study shows that stromal niches protect lung cancers from ALK inhibitors through multiple mechanisms, and targeting these mechanisms together is more effective than targeting them individually.

The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target.

The paper identifies genes involved in sulfur metabolism in Aspergillus fumigatus during infection, highlighting ShmB as a promising antifungal target due to its essential role in virulence and structural differences from the human enzyme.

PTEN and the PTEN-like phosphatase CnrN have both distinct and overlapping roles in a Dictyostelium chemorepulsion pathway

This study investigates the distinct and overlapping roles of PTEN and CnrN in Dictyostelium chemorepulsion by analyzing their effects on phosphoinositide levels and cell behavior.

Leveraging the p53 signaling pathway as a radio-sensitization strategy in endometrial cancer

This study investigates how p53 signaling alterations affect radiotherapy response in endometrial cancer and explores p53 as a radio-sensitization strategy.

Aspergillus fumigatus can display persistence to the fungicidal drug voriconazole

This study shows that some Aspergillus fumigatus isolates can persist in the presence of voriconazole, a fungicidal drug, and this persistence is associated with a distinct transcriptional profile and reduced treatment efficacy.

CD4 binding-site antibodies induced by a subtype B HIV-1 envelope trimer

This study shows that immunization with native-like HIV-1 subtype B Env trimers can induce CD4bs-directed broadly neutralizing antibodies in rabbits.

Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

This study shows hypoxia suppresses type I interferon signaling in ALI, leading to monocytopenia and unchecked inflammation, which can be mitigated by CSF1 administration.

Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

The paper identifies IL-10-producing CD4+ T cells that develop via T-bet dependence and Arg1 coexpression, promoting cytomegalovirus persistence.

Rapid carbon accumulation at a saltmarsh restored by managed realignment far exceeds carbon emitted in site construction

This study quantifies rapid carbon accumulation at a restored saltmarsh, showing it exceeds carbon emissions from construction, supporting managed realignment as a carbon-effective restoration method.

Pandemic, epidemic, endemic: B cell repertoire analysis reveals unique anti-viral responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

The paper analyzes B cell repertoires from SARS-CoV-2, Ebola, and RSV infections to identify distinct anti-viral immune responses and repertoire characteristics.

BET inhibitors synergize with anti-PD1 by rescuing TCF1+ progenitor exhausted CD8+ T cells in Acute Myeloid Leukemia

This study shows BET inhibitors enhance anti-PD1 therapy by reversing T cell exhaustion in AML, increasing CD8+ T cell function and reducing leukemia cells.

Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 Diabetes

This study shows that increased neuropeptide Y1 receptor signaling contributes to β-cell dysfunction in type 2 diabetes and that inhibiting this receptor with BIBO3304 improves β-cell function and glycaemic control.

A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemia

This study identifies nilotinib as an anti-inflammatory drug using a MALDI-TOF assay in AML-derived monocytes, showing it inhibits the p38-MK2/3 signaling axis.

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

Do examinations prepare students for higher education? A lesson from the Covid-19 lockdown.

This study compares bioscience knowledge of university students who took exams in 2019 versus those who did not in 2020 due to pandemic disruptions, finding no significant difference in knowledge or understanding.

A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

This study identifies a type I IFN-neutrophil-IL-18 axis driving immunopathology in genital HSV-2 infection.

Constitutive Androstane Receptor and Hepatitis B Virus X Protein Cooperatively Induce β-catenin-Activated Liver Tumors

This study shows that activating CAR with HBx in mice leads to liver tumors with strong β-catenin activation, mirroring human HBV-related HCC.

Lack of phenotypic variation despite population structure in larval utilization of pea aphids by populations of the lady beetle Hippodamia convergens

The study examines genetic and phenotypic differences in larval utilization of pea aphids by Western and Eastern populations of Hippodamia convergens, finding no phenotypic variation despite genetic structure.

Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence

This paper identifies methionine synthase as a promising antifungal target by showing its essentiality in Aspergillus fumigatus and validates its druggability using a genetic model of established infections.

Complement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.

This study identifies C5a-induced phosphoproteomic changes in human neutrophils that impair phagosomal maturation and acidification, leading to reduced killing of Staphylococcus aureus.

Hypoxia increases the tempo of evolution in glioblastoma

This study shows hypoxia accelerates tumour evolution by increasing cell division and mutation rates in glioblastoma.

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

The paper investigates resistance to ALK inhibitors in NSCLC, finding that resistance develops through gradual, multifactorial genetic and epigenetic changes rather than single mutations or reprogramming.

Antibiotic collateral sensitivity is contingent on the repeatability of evolution

This study shows that sequential antibiotic treatments may overestimate therapeutic benefits due to stochastic resistance or susceptibility outcomes in E. coli.

Pseudomonas aeruginosa Can Inhibit Growth of Streptococcal Species via Siderophore Production

This study shows that Pseudomonas aeruginosa inhibits growth of Streptococcus species by producing siderophores that compete for iron.

Temporally feathered intensity modulated radiation therapy: a planning technique to reduce normal tissue toxicity

This paper introduces a novel radiation therapy planning technique called temporally feathered radiotherapy (TFRT) that reduces normal tissue toxicity by optimizing the timing of radiation doses.

Signatures of insecticide selection in the genome of Drosophila melanogaster.

This study identifies genetic mutations associated with resistance to two insecticides in Drosophila melanogaster using GWAS and finds that resistance mechanisms differ between insecticide classes.

Optimal Therapy Scheduling Based on a Pair of Collaterally Sensitive Drugs

This paper develops a dynamical model to determine optimal drug switching schedules for collaterally sensitive drugs in cancer treatment, finding that the initial drug phase should be shorter than its effective duration.