Author

K. Ahmad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:ChIP-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:mouse· 2

Frequent Co-Authors

S. Henikoff· 4 shared D. H. Janssens· 3 shared E. C. Holland· 2 shared F. Szulzewsky· 2 shared J. F. Sarthy· 2 shared J. G. Henikoff· 2 shared R. M. Paranal· 2 shared S. Kugel· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

S. Henikoff

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Author profile →

4 papers

Recent·Most cited

RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples

S. Henikoff, Y. Zheng, R. M. Paranal, Y. Xu, J. E. Greene, J. G. Henikoff, Z. R. Russell, F. Szulzewsky, H. N. Thirimanne, S. Kugel, E. C. Holland, K. Ahmad

The paper identifies RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples, linking it to tumor progression and aneuploidy.

bioRxiv · Feb 28, 2024Cancer Biology

KMT2A oncoproteins induce epigenetic resistance to targeted therapies

D. H. Janssens, M. Duran, D. J. Otto, W. Wu, Y. Xu, D. Kirkey, C. G. Mullighan, J. S. Yi, S. Meshinchi, J. F. Sarthy, K. Ahmad, S. Henikoff

This study shows KMT2A oncoproteins drive lineage-switching and epigenetic resistance in leukemia by dynamically binding chromatin and persisting as ENL-marked lesions despite therapy.

bioRxiv · Dec 29, 2023 · PreprintCancer Biology

Epigenomic analysis of Formalin-Fixed Paraffin-Embedded samples by CUT&Tag

S. Henikoff, J. G. Henikoff, K. Ahmad, R. M. Paranal, D. H. Janssens, Z. R. Russell, F. Szulzewsky, S. Kugel, E. C. Holland

This study modifies the CUTAC protocol to enable high-resolution epigenomic analysis of FFPE samples, identifying regulatory element differences in mouse brain tumors.

bioRxiv · Jun 20, 2023Cancer Biology

Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes

N. De Sarkar, R. D. Patton, A.-L. Doebley, B. Hanratty, A. J. Kreitzman, J. F. Sarthy, M. Ko, M. Adil, S. Brahma, M. P. Meers, D. H. Janssens, L. S. Ang, I. Coleman, A. Bose, R. F. Dumpit, , G. Ha

This paper identifies nucleosome patterns in ctDNA that distinguish advanced prostate cancer phenotypes, achieving high accuracy in classification using a prediction model.

bioRxiv · Jun 21, 2022Cancer Biology