A. Bose

A Recurrent Neural Network for Rhythmic Timing

This study trains a biologically constrained RNN on rhythmic timing tasks and identifies neural mechanisms that replicate observed dynamics in monkey neural recordings.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

The phototrophic bacteria Rhodomicrobium spp. are novel chassis for bioplastic production

This study identifies two phototrophic bacteria, Rhodomicrobium spp., as novel chassis for PHB production, showing varying PHB titers across different growth conditions.

Improving bioplastic production by Rhodopseudomonas palustris TIE-1 using synthetic biology and metabolic engineering

This paper enhances bioplastic production in Rhodopseudomonas palustris TIE-1 through genetic modifications and a phage integration system.

Connexin 43 mediated collective cell migration is independent of Golgi orientation

This study shows that Connexin 43 promotes collective cell migration by reducing Golgi reorientation, independent of directed secretory trafficking.

Improved Ethanol Tolerance and Production in Pyruvate Dehydrogenase Mutant of Saccharomyces cerevisiae

This study creates a Pyruvate Dehydrogenase (PDH) deficient S. cerevisiae strain that shows improved ethanol production and tolerance.

A universal stress protein is essential for the survival of Mycobacterium tuberculosis

This study identifies Rv1636 as an essential cAMP-binding protein in Mycobacterium tuberculosis that regulates intracellular cAMP levels and is required for bacterial survival.

KDM6A loss sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

This study shows that KDM6A loss in AML increases sensitivity to PARP and BCL2 inhibitors, suggesting a new combination therapy approach for KDM6A-mutant AML.

Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes

This paper identifies nucleosome patterns in ctDNA that distinguish advanced prostate cancer phenotypes, achieving high accuracy in classification using a prediction model.

FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction

This study shows that FGF21-PEG normalizes plasma glucose in two mouse diabetes models, even when insulin receptor function is impaired.

Hemoglobin drives inflammation and initiates antigen spread and nephritis in lupus

This study shows that hemoglobin, particularly ferric hemoglobin, drives inflammation and autoantibody production in lupus by interacting with autoantigens and activating immune cells.

Sustainable Production of the Biofuel n-Butanol by Rhodopseudomonas palustris TIE-1

This study introduces an n-butanol biosynthesis pathway into Rhodopseudomonas palustris TIE-1 to produce biofuel from CO2 using sustainable resources.

Genetic redundancy in iron and manganese transport in the metabolically versatile bacterium Rhodopseudomonas palustris TIE-1

This study investigates Fe and Mn transport in Rhodopseudomonas palustris TIE-1, showing functional redundancy among transporters and their regulation by Fe and oxygen availability.

14-3-3γ prevents centrosome duplication by inhibiting NPM1 function.

The paper identifies conserved residues in 14-3-3γ that regulate its interaction with NPM1, affecting centrosome duplication.

The haploinsufficient tumor suppressor Tip60 negatively regulates the oncogenic Aurora B kinase

This study shows Tip60 acetylates AurkB, reducing its stability and activity, suggesting Tip60 downregulation increases AurkB activity in cancer.

Aurora kinase A mediated phosphorylation of mPOU is critical for skeletal muscle differentiation

The paper shows that Aurora kinase A phosphorylates POU6F1 at Ser197, inhibiting its DNA binding and slowing skeletal muscle differentiation.

Pancreatic tumor organoids for modeling in vivo drug response and discovering clinically-actionable biomarkers

This paper demonstrates that pancreatic tumor organoids (PDOs) recapitulate PDX models' features and can identify clinically-actionable biomarkers in blood.

Methane-linked mechanisms of electron uptake from cathodes by Methanosarcina barkeri

This paper confirms Methanosarcina barkeri can uptake electrons from cathodes, linking it to increased methane production and identifying both hydrogenase-mediated and hydrogenase-independent pathways for cathodic electron uptake.

Improving microbial electrosynthesis of polyhydroxybutyrate (PHB) from CO2 by Rhodopseudomonas palustris TIE-1 using an immobilized iron complex modified cathode