Cell BiologybioRxiv
A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial differentiation
J. Ostrop, R. Zwiggelaar, M. T. Pedersen…·M. J. Oudhoff
This study develops a semi-automated intestinal organoid screening method to identify epigenetic regulators of epithelial differentiation, finding that inhibiting type I PRMTs enhances differentiation and blocks adenoma growth.
DOI 10.3389/fcell.2020.618552