Tuft cell-derived acetylcholine is an effector of type 2 immunity and directly targets helminth parasites in the gut lumen
M. Ndjim, F. Herbert, I. Gasmi, C. Josephine, S. Henry, E. Turtoi, S. Thirard, A. Giordano, C. Ciancia, C. Britton, E. Devaney, T. N. McNeilly, S. Berrard, A. Turtoi, R. M. Maizels, , P. Jay
The paper shows tuft cells release acetylcholine to directly target helminth parasites in the gut, enhancing type 2 immunity.
bioRxiv · Dec 8, 2023 · PreprintImmunology