Irgm2 and Gate-16 cooperatively dampen targeting of caspase-11 to Gram-negative bacterial products
E. Eren, R. Planes, S. Bagayoko, P.-J. Bordignon, K. Chaoui, A. Hessel, K. Santoni, M. Pinilla, O. Schiltz, J. C. Howard, M. Yamamoto, E. Meunier
This study identifies Irgm2 and Gate-16 as cooperative regulators that dampen non-canonical inflammasome activation by reducing caspase-11 targeting to intracellular bacteria.
bioRxiv · Mar 6, 2020Immunology