K. Santoni

Leishmania infantum-exploited Nrf2 transcription factor as a virulence process to escape macrophage-driven ferroptosis-like leishmanicidal process

This study identifies Nrf2 as a key factor in Leishmania infantum infection by protecting macrophages from ferroptosis-like cell death, suggesting it as a therapeutic target for visceral leishmaniasis.

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption upon Pseudomonas infection

This paper shows that Pseudomonas aeruginosa's Exotoxin A activates the NLRP1 inflammasome via EEF2 inactivation, causing epithelial damage and pyroptosis, and identifies ZAK as a key sensor in this process.

Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection

This study shows that Pseudomonas aeruginosa induces Caspase-1-dependent pyroptosis in neutrophils, leading to incomplete NETosis and promoting bacterial spread.

Phospholipid peroxidation fuels ExoU phospholipase-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology

This study identifies phospholipid peroxidation as a mechanism enhancing ExoU phospholipase activity, leading to cell necrosis and supporting Pseudomonas aeruginosa pathogenesis.

Irgm2 and Gate-16 cooperatively dampen targeting of caspase-11 to Gram-negative bacterial products

This study identifies Irgm2 and Gate-16 as cooperative regulators that dampen non-canonical inflammasome activation by reducing caspase-11 targeting to intracellular bacteria.