Pharmacology & ToxicologybioRxivPreprint
Nephrotoxicity of the BRAF-kinase inhibitor Vemurafenib isdriven by off-target Ferrochelatase inhibition
Y. Bai, J. Y. Kim, L. A. Jayne…·N. S. Pabla
This study identifies off-target ferrochelatase inhibition as a mechanism of vemurafenib-induced nephrotoxicity in renal tubular epithelial cells.