Author

K. D. Pyles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

D. R. Kamm· 3 shared K. S. McCommis· 3 shared M. C. Sharpe· 2 shared A. Kovacs· 1 shared B. A. Neuschwander-Tetri· 1 shared B. Fisk· 1 shared B. J. DeBosch· 1 shared B. N. Finck· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersPathology

D. R. Kamm

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Enhancing Hepatic MBOAT7 Expression Does Not Improve Nonalcoholic Steatohepatitis in Mice

M. C. Sharpe, K. D. Pyles, T. Hallcox, D. R. Kamm, M. Piechowski, B. Fisk, C. J. Albert, D. H. Carpenter, B. Ulmasov, D. A. Ford, B. A. Neuschwander-Tetri, K. S. McCommis

This study shows that increasing MBOAT7 expression in mice with NASH does not significantly improve liver histology, likely due to low arachidonoyl-CoA substrate levels.

bioRxiv · Mar 24, 2022 · PreprintPathology

MSDC-0602K, A Novel Insulin-Sensitizer Improves Insulinemia and Fatty Liver Disease Alone and in Addition to Liraglutide in Mice

D. R. Kamm, K. D. Pyles, M. C. Sharpe, L. Healy, J. R. Colca, K. S. McCommis

This study evaluates a novel insulin-sensitizer MSDC-0602K in combination with Liraglutide, showing improved glycemia and liver disease in diabetic and NASH mouse models.

bioRxiv · Dec 10, 2020Pharmacology & Toxicology

Ketogenic Diet Prevents Heart Failure from Defective Mitochondrial Pyruvate Metabolism

K. S. McCommis, A. Kovacs, C. J. Weinheimer, T. M. Shew, T. R. Koves, O. R. Ilkayeva, D. R. Kamm, K. D. Pyles, M. T. King, R. L. Veech, B. J. DeBosch, D. M. Muoio, R. W. Gross, B. N. Finck

This study shows that a ketogenic diet prevents heart failure in mice with defective mitochondrial pyruvate metabolism by reversing cardiac remodeling and dysfunction.

bioRxiv · Feb 21, 2020Physiology