A. Kovacs

Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension

This paper develops a two-hit mouse model of HFpEF combining diet-induced obesity and renin-mediated hypertension, showing key features of the disease and response to therapy.

Genetic Mapping of Monocyte Fate Decisions Following Myocardial Infarction

The paper maps monocyte differentiation trajectories in the infarcted heart using genetic lineage tracing and single-cell RNA-sequencing, identifying a protective IFN-responsive macrophage subset.

Deep physico-chemical characterization of the serum antibody response using a dual-titration microspot assay

The paper introduces a fluorescent dual-titration microspot assay to quantitatively measure antigen-specific serum antibodies, providing physico-chemical parameters for immunological analysis.

Hypoxia Sensing in Resident Cardiac Macrophages Regulates Monocyte Fate Specification following Ischemic Heart Injury

This study shows that hypoxia sensing in cardiac macrophages influences monocyte differentiation into inflammatory states after heart injury.

Dapagliflozin improves endothelial integrity and hemodynamics in endotoxin treated mice through an apolipoprotein M dependent pathway

This study shows dapagliflozin improves hemodynamics and endothelial integrity in endotoxin-treated mice via the ApoM/S1P pathway by preserving megalin expression.

Absolute quantitation of serum antibody reactivity using the Richards growth model for antigen microspot titration

The paper introduces a method to absolutely quantify serum antibody reactivity using a Richards growth model applied to antigen microspot titration.

TRAF2, an innate immune sensor, reciprocally regulates mitophagy and inflammation to maintain cardiac myocyte homeostasis.

This study shows TRAF2 regulates mitophagy and inflammation in cardiac myocytes to prevent cell death and maintain homeostasis.

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

Apolipoprotein M attenuates anthracycline cardiotoxicity and lysosomal injury

This paper investigates the role of apolipoprotein M in anthracycline cardiotoxicity, finding that ApoM protects against cardiac dysfunction and lysosomal injury through the autophagy-lysosome pathway.

Tumor-infiltrating nerves create an electro-physiologically active microenvironment and contribute to treatment resistance

The paper shows that tumor-infiltrating nerves contribute to treatment resistance and that chemotherapy increases tumor innervation.

Ketogenic Diet Prevents Heart Failure from Defective Mitochondrial Pyruvate Metabolism

This study shows that a ketogenic diet prevents heart failure in mice with defective mitochondrial pyruvate metabolism by reversing cardiac remodeling and dysfunction.