B. N. Finck

This study shows that intermittent glucocorticoid treatment rescues both energy and mass in aging-related sarcopenia via the PGC1alpha-Lipin1 pathway in muscle cells.

This study investigates how liver mitochondrial pyruvate carrier deficiency affects de novo lipogenesis and glycerol-mediated gluconeogenesis in mice, finding impaired DNL but no reduction in intrahepatic lipid and unchanged glucose levels despite reduced glycerol metabolism.

This study shows that loss of both MPC and ALT2 increases susceptibility to oxidative stress and worsens liver injury in mice, while ALT2 induction reduces APAP toxicity.

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.

This study shows exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic IL-6 signaling through inter-organ crosstalk, but does not enhance liver regeneration.

This study shows that Mogat1 ASOs improve glucose metabolism in mice independently of Mogat1 knockdown or IFNAR-1 activation.

This study shows lipin-1 regulates lipid catabolism in pro-resolving macrophages by promoting fatty acid oxidation and TCA cycle function during IL-4 responses.

This study shows that lipin-1's transcriptional co-regulatory activity protects against atherosclerosis, while its enzymatic activity promotes it, using a mouse model with myeloid cell-specific lipin-1 deletion.

This study shows that a ketogenic diet prevents heart failure in mice with defective mitochondrial pyruvate metabolism by reversing cardiac remodeling and dysfunction.

This study shows that lipin-1's transcriptional co-regulator activity is necessary for macrophage polarization and wound healing, as its absence impairs IL-4 mediated gene expression and tissue repair.

The paper shows that TCA cycle activity influences ER stress via NADPH and glutathione redox metabolism in mouse hepatocytes.