K. S. McCommis

The paper shows that lipid nanodomains modulate HCN channels in DRG neurons, affecting pain signaling and neuronal firing.

This study shows that loss of both MPC and ALT2 increases susceptibility to oxidative stress and worsens liver injury in mice, while ALT2 induction reduces APAP toxicity.

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.

This study shows that increasing MBOAT7 expression in mice with NASH does not significantly improve liver histology, likely due to low arachidonoyl-CoA substrate levels.

This study evaluates a novel insulin-sensitizer MSDC-0602K in combination with Liraglutide, showing improved glycemia and liver disease in diabetic and NASH mouse models.

This study shows that a ketogenic diet prevents heart failure in mice with defective mitochondrial pyruvate metabolism by reversing cardiac remodeling and dysfunction.

The paper shows that TCA cycle activity influences ER stress via NADPH and glutathione redox metabolism in mouse hepatocytes.