Dysregulation of Acid Ceramidase-mediated Sphingolipid Metabolism Contributes to Tumor Progression in Tuberous Sclerosis Complex
A. Astrinidis, C. Li, E. Y. Zhang, X. Zhao, S. Zhao, M. Guo, R. Huang, A. A. Zhang, E. J. Kopras, N. Gupta, E. P. Smith, E. Fugate, D. Lindquist, K. Wikenheiser-Brokamp, K. D. Setchell, , J. J. Yu
This study identifies dysregulated sphingolipid metabolism in TSC2-null cells and tumors, showing that ASAH1 inhibition reduces cell viability and tumor growth in TSC and LAM.
bioRxiv · Sep 25, 2022 · PreprintCell Biology