S. Zhao

BOOST: a robust ten-fold expansion method on hour-scale

BOOST is a rapid expansion microscopy method that achieves ~10x linear expansion in 90 minutes using microwave-assisted chemistry, improving throughput for various biological specimens.

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

Macrophages facilitate interclonal cooperation-induced tumor heterogeneity and malignancy by activating the innate immune signaling

This study shows that macrophages in Drosophila tumors promote heterogeneity and malignancy by activating innate immune signaling through the Toll pathway.

PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/BNIP3L-dependent mitophagy

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

This study shows that AARS2 protects cardiomyocytes from ischemia by modulating PKM2-mediated metabolism, improving cardiac function after myocardial infarction.

2D Label-free Prediction of Multiple Organelles Across Different Transmitted-light Microscopy Images with Bag-of-Experts

This paper introduces a 'Bag-of-Experts' model for label-free prediction of multiple organelles across transmitted-light microscopy images, showing generalizability across imaging conditions.

Realigning representational drift in mouse visual cortex by flexible brain-machine interfaces

This study uses flexible electrodes to track and model representational drift in mouse visual cortex, enabling a stable decoder for brain-machine interfaces.

Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after Total Neoadjuvant Therapy including Stereotactic Body Radiotherapy

This study shows that combining FOLFIRINOX with stereotactic body radiotherapy remodels pancreatic ductal adenocarcinoma, improving stromal and metabolic features and prognosis.

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Bioluminescence Imaging of Potassium Ion Using a Sensory Luciferin and an Engineered Luciferase

This paper develops a bioluminescent indicator for potassium ions using a modified luciferin and engineered luciferase, validated in cell lines, neurons, and live mice.

Initial Characterization of Canine T-cell Receptor Repertoires Using RNA-seq Data from Different Diseases and Tissues

This study characterizes the canine T-cell receptor repertoire using RNA-seq data from various diseases and tissues, revealing similarities and differences with human TCR repertoires.

Self-inspired learning to denoise for live-cell super-resolution microscopy

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 RNP

This study demonstrates that lipid nanoparticle-delivered thermostable Cas9 RNPs achieve high-efficiency genome editing in mouse liver and lung tissues.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

This paper develops an injectable platform for ultra-long-term hydrophilic drug delivery, achieving sustained release over six months in vivo.

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

This study shows GABRD promotes breast cancer progression by regulating the cell cycle through CDK1 interaction.

Decoding genetic architecture of dog complex traits by constructing fine-scale genomic ancestry of admixture

The paper develops a method to reconstruct fine-scale genomic ancestry in admixed dog breeds and identifies genes associated with body size traits.

Efficient Enumeration and Visualization of Helix-coil Ensembles

The paper introduces an algorithm to efficiently approximate helix-coil ensembles by enumerating the most probable configurations, enabling analysis of ensemble properties and folding mechanisms.

Population genomics of Aspergillus sojae is shaped by the food environment

This study examines how long-term use of Aspergillus sojae in soy fermentation shaped its population structure, genome variation, and phenotypic traits, revealing reduced genetic diversity and loss of aflatoxin production.

Deep learning classification of ex vivo human colon tissues using spectroscopic OCT

This study uses deep learning to classify ex vivo human colon tissues with spectroscopic OCT, achieving 88.9% accuracy in distinguishing tissue types.

Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations

A computational model predicts influenza virus evolution and aids in vaccine strain selection by modeling site-wise mutation dynamics.

Single-cell precision nanotechnology in vivo

This study demonstrates DNA origami can be directed in vivo to target immune cells and cancer metastases, showing potential for precision drug delivery.

A framework for Frizzled-G protein coupling and implications to the Wnt-PCP signaling pathways

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.

Dynamic phytomeric growth contributes to local adaptation in barley

This study shows that domestication in barley extends the apical meristematic phase for node initiation but restricts internode elongation, with genetic factors influencing these processes along latitudinal and longitudinal gradients.

Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells

This study maps ex vivo terminal erythropoiesis from umbilical cord blood mononuclear cells and pluripotent stem cells, identifying differences in regulatory dynamics and CD99 expression affecting erythroid expansion and maturation.

Immunoproteasomal Processing of Isolevuglandin Adducts in Hypertension

This study identifies the immunoproteasome's role in processing and presenting isoLG-adducts, linking it to hypertension and inflammation.

The characterisation of antimicrobial resistant Escherichia coli from dairy calves

This study characterizes antimicrobial resistant E. coli in dairy calves, identifying plasmid-mediated resistance and distinct phylogenetic lineages.

Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions

This study uses single-cell RNA sequencing to analyze fibroblast heterogeneity and interactions in Crohn's disease strictures, identifying CDH11 as a potential therapeutic target.

Widespread PRC barrel proteins play critical roles in archaeal cell division

This study identifies three PRC barrel proteins in Haloferax volcanii essential for archaeal cell division, showing their conservation and role in division across haloarchaea.