N. Gupta

Chrom-Sig: de-noising 1-dimensional genomic profiles by signal processing methods

Chrom-Sig de-noises 1-dimensional genomic coverage tracks using signal processing to separate signal from noise, validated across multiple datasets.

Computational screening of T-muurolol for an alternative antibacterial solution against Staphylococcus aureus infections: A state-of-the-art phytochemical-based drug discovery approach

This study identifies T-muurolol as a potential antibacterial agent against Staphylococcus aureus through computational screening, showing interactions with key bacterial proteins and favorable pharmacological properties.

Therapeutic Activity of Resolvin D1 (RvD1) in Murine MASH

This study investigates how RvD1 reduces inflammation, cell death, and fibrosis in MASH by targeting Stat1, ER stress, and MMP pathways.

G6PD deficiency mediated impairment of iNOS and lysosomal acidification affecting phagocytotic clearance in microglia in response to SARS-CoV-2

This study shows that G6PD deficiency in microglia impairs iNOS-mediated NO production and lysosomal acidification, leading to reduced phagocytosis of SARS-CoV-2 and increased COVID-19 severity.

An integrative proteomics approach identifies tyrosine kinase KIT as a novel therapeutic target for SPINK1-positive prostate cancer.

The paper identifies KIT as a therapeutic target for SPINK1-positive prostate cancer through integrative proteomics and shows KIT inhibition reduces tumor growth and metastasis.

A broadly protective CHO cell expressed recombinant spike protein subunit based vaccine (IMT-CVAX) against SARS-CoV-2

This paper develops a recombinant spike protein subunit vaccine (IMT-CVAX) against SARS-CoV-2 that elicits broad neutralization against variants and provides protection in animal models.

Biogenesis of specialized lysosomes in differentiated keratinocytes relies on close apposition with the Golgi apparatus

This study identifies a novel mechanism where Golgi-lysosome contact in differentiated keratinocytes supports specialized lysosome function and protein secretion.

Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive Cells

This study identifies PBX1 as a critical regulator of LAM progression by analyzing scRNA-seq data and validating its role in LAM cell survival and lung colonization.

Dysregulation of Acid Ceramidase-mediated Sphingolipid Metabolism Contributes to Tumor Progression in Tuberous Sclerosis Complex

This study identifies dysregulated sphingolipid metabolism in TSC2-null cells and tumors, showing that ASAH1 inhibition reduces cell viability and tumor growth in TSC and LAM.

Human endogenous retrovirus-R envelope is a host restriction factor against severe acute respiratory syndrome-coronavirus-2

The paper identifies HERV-R envelope as a host restriction factor that inhibits SARS-CoV-2 replication through ERK and p38 MAPK signaling.

Caveolae promote successful abscission by controlling intercellular bridge tension during cytokinesis

The paper shows caveolae reduce intercellular bridge tension during cytokinesis, enabling ESCRT-III assembly and successful abscission.

The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression

This study identifies that the co-deletion of CIC and ERF leads to ETV1 activation, driving prostate cancer progression without fusion events.

An in vitro and in vivo approach for the isolation of Omicron variant from human clinical specimens

The paper isolates the Omicron variant from Syrian hamsters and compares its genetic changes to human clinical specimens and Vero CCL-81 cell passages.

Cancer/Testis genes are predictive of breast tumor subtypes

The paper identifies HORMAD1 and CT83 as Cancer/Testis genes predictive of basal-like breast tumors and shows their epigenetic regulation and prognostic significance.

Microbial induced calcite precipitation can consolidate martian and lunar regolith simulants

This paper shows that microbial induced calcite precipitation can create strong bricks from Martian and lunar regolith simulants using bacteria and additives.

Horizontal transfer of a conserved npc-2 like effector gene in rust fungi that suppresses cell death in plants

The paper identifies a horizontally transferred NPC2-like effector gene from rust fungi that suppresses plant cell death by lipid binding, showing functional conservation with animal NPC2 proteins.

Comparative secretomics identifies conserved WAxR motif-containing effectors in rust fungi that suppress cell death in plants

This study identifies a novel WAxR motif in rust fungal effectors that suppress plant cell death, using comparative secretome analysis and functional validation.

Neutralization of Delta variant with sera of Covishield vaccinees and COVID-19 recovered vaccinated individuals

This study evaluates immune response in Covishield vaccinated and recovered individuals against the Delta variant, finding higher protection in breakthrough cases and recovered individuals compared to single or double vaccinated groups.

Neutralization against B.1.351 and B.1.617.2 with sera of COVID-19 recovered cases and vaccinees of BBV152

This study assesses the neutralization efficacy of sera from COVID-19 recovered cases and BBV152 vaccinees against SARS-CoV-2 variants B.1.351 and B.1.617.2, showing reduced titers but still protective responses.

Isolation of SARS-CoV-2 B.1.1.28.2 P2 variant and pathogenicity comparison with D614G variant in hamster model

The paper isolates the SARS-CoV-2 B.1.1.28.2 (P.2) variant from travelers and compares its pathogenicity to the D614G variant in hamsters, finding it more severe and with reduced neutralization.

Isolation and characterization of SARS-CoV-2 VOC, 20H/501Y.V2, from UAE travelers

The paper isolates and characterizes the SARS-CoV-2 VOC 20H/501Y.V2 (B.1.351) from UAE travelers to India to assess vaccine efficacy.

Neutralization potential of Covishield vaccinated individuals sera against B.1.617.1

This study compares neutralizing antibody responses in Covishield-vaccinated individuals and COVID-19 recovered subjects against B.1 and B.1.617.1 variants, finding higher neutralization in recovered subjects.

SARS CoV-2 variant B.1.617.1 is highly pathogenic in hamsters than B.1 variant

This study compares the pathogenicity of SARS-CoV-2 variants B.1 and B.1.617.1 in hamsters, finding B.1.617.1 causes greater body weight loss, higher viral load, and more severe lung lesions.

Neutralization of B.1.1.28 P2 variant with sera of natural SARS-CoV-2 infection and recipients of BBV152 vaccine

This study evaluates the neutralizing efficacy of B.1.1.28.2 variant against sera from natural infection and BBV152 vaccine recipients, showing reduced neutralization compared to D614G.

Neutralization of variant under investigation B.1.617 with sera of BBV152 vaccinees

The paper assesses the neutralizing ability of sera from BBV152 vaccinees and convalescent COVID-19 patients against B.1.617 variants.

Physiological Substrates and Ontogeny-Specific Expression of the Ubiquitin Ligases MARCH1 and MARCH8

This study identifies MARCH1 and MARCH8 as specialized regulators of CD4+ T cell immunity in distinct cellular compartments by analyzing their substrates and expression in mice.

Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

The loss of IL-31 signaling attenuates bleomycin-induced pulmonary fibrosis

This study shows that blocking IL-31 signaling reduces collagen deposition and lung function decline in bleomycin-induced pulmonary fibrosis.

The new kid on the block: A dominant-negative mutation of phototropin1 enhances carotenoid content in tomato fruits

A dominant-negative mutation in phototropin1 increases carotenoid content and alters metabolite and protein profiles in tomato fruits.

Evaluation of Safety and Immunogenicity of an Adjuvanted, TH-1 Skewed, Whole Virion Inactivated SARS-CoV-2 Vaccine - BBV152

This study evaluates the safety and immunogenicity of a SARS-CoV-2 vaccine BBV152 in mice, rats, and rabbits, showing high antibody titers and Th1-biased responses with the TLR7/8 agonist adjuvant.